منابع مشابه
Automated synthesis of 11C-labelled radiopharmaceuticals: imipramine, chlorpromazine, nicotine and methionine.
This article describes a method by which about a hundred mCi of different radiopharmaceuticals (imipramine, chlorpromazine, nicotine or methionine) may be prepared in 3(t35 min with no irradiation risk to the operators, All operations (preparation of precursor. methylation of the monodesmethyl derivative, purification and sterilisation of the end product) are carried out in a closed shielded ho...
متن کاملAutomated synthesis of radiopharmaceuticals for PET: an apparatus for [1-11C]labelled aldoses
This paper describes an instrumentation system for positron emission tomography (PET). A variety of [1-(11)C]labelled aldoses, such as [1-(11)C]-D-glucose, and galactose by a modification of the Kiliani-Fischer method have been produced. The instrumentation is fully automatic and consists of a synthesis system and control system. The synthesis system has the following functions: supplying reage...
متن کاملSynthesis of 11C-Labelled Ureas by Palladium(II)-Mediated Oxidative Carbonylation.
Positron emission tomography is an imaging technique with applications in clinical settings as well as in basic research for the study of biological processes. A PET tracer, a biologically active molecule where a positron-emitting radioisotope such as carbon-11 has been incorporated, is used for the studies. Development of robust methods for incorporation of the radioisotope is therefore of the...
متن کاملSynthesis of 11C-labelled thymidine for tumor visualization using positron emission tomography.
A no-carrier added synthesis of [11C]thymidine from cyclotron produced [11C]methyl iodide is presented. The bis-silylated derivative of the lithium salt of 5-bromo-2'-deoxyuridine is treated with [11C]methyl iodide in THF at -50 degrees C giving 20-30 mCi [11C]thymidine in a 40-70% radiochemical yield. Purification is performed by reversed phase chromatography on a C18 column. The whole procedu...
متن کاملImproved synthesis of [11C]SA4503, [11C]MPDX and [11C]TMSX by use of [11C]methyl triflate.
Recently we have clinically used three new radioligands, [11C]SA4503, [11C]MPDX, and [11C]TMSX, for mapping sigma1, adenosine A1, and adenosine A2A receptors, respectively, in the human brain by positron emission tomography. These radioligands are synthesized by methylation of the respective demethyl precursor with [11C]methyl iodide. Here we demonstrate the improved syntheses of these compound...
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ژورنال
عنوان ژورنال: Acta Chemica Scandinavica
سال: 1984
ISSN: 0904-213X
DOI: 10.3891/acta.chem.scand.38b-0001